The Holler Family

The Holler Family

Over the last 20+ years, The Hollers have built a flock of genetically selected carriers for the GM1 gangliosidosis trait.   GlycoScience Research Inc (GSR), located near White, SD was incorporated to develop a safe, natural source of GM1 for ganglioside research and therapeutic use. Our mission is to produce and promote ovine GM1 ganglioside as a treatment for Huntington’s Disease and other neurological diseases.  http://straussbrands.com/family-farmers/susan-larry-holler

The management team of GSR currently consists of its founders, Larry and Sue Holler.  Larry has a DVM degree from Kansas State University and a Ph.D. from Washington State University.  He is currently employed as a diagnostic pathologist and animal reproductive disease specialist in the Veterinary and Biomedical Sciences Department at South Dakota State University.  Connect with him on LinkedIn.  Sue Holler has a B.S. in Animal Science and an M.S. in Reproductive Physiology from Purdue University.  She has been employed in research, teaching and diagnostic positions at University of Idaho, Washington State University, and South Dakota State University respectively.  Together with Mike Nelson and their 2 sons, Paul (20) and Matthew (16), they manage the farm and research flock.

For 20+ years, Dr. Greg and Pam Taylor (Clear Lake, SD) have also maintained a flock of GM1 gangliosidosis sheep originating from our genetic line.  Currently, we have 17 cooperating flocks pushing available ewe totals to over 5000.

6 Responses to About

  1. Tricia Wempe says:

    I finally am viewing your website for the first time as a part of my reseach for the PPT I’m creating. Sorry it took so long for me to view it. I thought that it was not launched yet until I googled the key term, “Glycoscience Research Inc.”

    Nice website. Keep it up. I’m hopeful to get this tested in the near future in humans as a prospective HD therapuetic drug.

    –Tricia Wempe

    • sueholler says:

      Thanks for taking time to visit the farm. We hope that as more people become aware of GM1 we can make progress toward improving HD patients quality of life. Thanks for your efforts. It’s tough for a team of 2 to keep up with everything on the home front and try to promote GM1 too. Keep in touch.
      -Sue Holler

  2. Staci Risseeuw says:

    I am so glad that I found your website because I am very interested in how the research and development of GM1 in the pursuit for the cure of Huntington’s disease is progressing. My father has been involved in the process and I wanted to keep up with this exciting new advancement in medicine.


  3. Liz McMillan says:

    Sue, we met up again at the SDBiotech Symposium (I’m related to Lucas & Casey in Brookings)… My colleague and I have been talking about our Community Lecture Series and whether you or Larry would be candidates for discussing your work. The Lecture Series is aimed at sharing research in teh region with the community. It’s held monthly here in Sioux Falls and we’ve got approx 100 attendees (including hs students). Would either of you have some time in the near future to discuss this?


    • sueholler says:

      Larry and I are planning to attend the Sanford Rare Disease Symposium Feb. 28 and March 1. Would it be possible to meet with you and some of your colleagues, who would be interested in GM1, on Thursday?


  4. Tricia Wempe says:

    Larry and Sue,

    I’m so grateful for your ministry/work to help HD families.

    May God speed your work to get GM1 into FDA human clinical trials!

    Thank you!

    Sincerely, –Tricia

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